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Information about Diflucan.
Fluconazole passes into breast milk but is unlikely to harm a nursing infantConsult your doctor before breast-feeding.
Before taking Diflucantell your doctor if you have liver diseasekidney diseasea heart rhythm disorderor a history of Long QT syndrome.
AstemizoleConcomitant administration of fluconazole with astemizole may decrease the clearance of astemizoleResulting increased plasma concentrations of astemizole can lead to QT prolongation and rare occurrences of torsades de pointesCoadministration of fluconazole and astemizole is contraindicatedsee section 4.3
ErythromycinConcomitant use of fluconazole and erythromycin has the potential to increase the risk of cardiotoxicityprolonged QT intervaltorsades de pointesand consequently sudden heart deathCoadministration of fluconazole and erythromycin is contraindicatedsee section 4.3
Diflucan has been associated with rare cases of serious hepatic toxicity including fatalitiesprimarily in patients with serious underlying medical conditionsIn cases of fluconazole associated hepatotoxicityno obvious relationship to total daily doseduration of therapysex or age of patient has been observedFluconazole hepatotoxicity has usually been reversible on discontinuation of therapy.
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